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- Bioss
- bs-20601P
- 2025年10月16日
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500ug
| 产品编号 | bs-20601P |
| 英文名称 | NOS2 Antibody Blocking Peptide |
| 中文名称 | 一氧化氮合成酶-2（诱导型）封闭多肽 |
| 英文别名 | i NOS; Nitric Oxide Synthase, Inducible; HEP NOS; Hepatocyte NOS; HEPNOS; Inducible nitric oxide synthase; Inducible NO synthase; Inducible NOS; INOS; Inosl; MAC NOS; Macrophage NOS; Nitric oxide synthase 2 inducible macrophage; Nitric oxide synthase 2A (inducible hepatocytes); Nitric oxide synthase inducible; NOS 2; NOS 2A; NOS; Nos II; NOS type II; Nos2; NOS2A; NOS2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cancer Metabolism > Cellular metabolic process Cancer > Cancer Metabolism > Response to hypoxia Metabolism > Pathways and Processes > Metabolism processes > Hypoxia Neuroscience > Neurotransmission > Nitric Oxide > NOS |
| 亚基 | Homodimer. Binds SLC9A3R1. |
| 亚细胞定位 | Cytosol |
| 组织特异性 | Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. |
| 相似性 | Belongs to the NOS family.
Contains 1 FAD-binding FR-type domain. Contains 1 flavodoxin-like domain. |
| 功能 | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) & endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. All NOS isoforms contain calmodulin, nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) binding domains. Nitric oxide synthase is expressed in liver, macrophages, hepatocytes, synoviocytes, stimulated glial cells and smooth muscle cells. Cytokines such as interferon-gamma (IFN), tumor necrosis factor (TNF), interleukin-1 and -2, and lipopolysaccarides (LPS) cause an increase in iNOS mRNA, protein, and activity levels. Protein kinase C-stimulating agents exhibit the same effect on iNOS activity. After cytokine induction, iNOS exhibits a delayed activity response which is then followed by a significant increase in NO production over a long period of time. Human iNOS is regulated by calcium/calmodulin (in contrast with mouse NOS2). |
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NOS2 Antibody Blocking Peptide(bs-20601P)-500ug
￥880
