- ￥880
- Bioss
- bs-11518P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11518P |
| 英文名称 | FOXD3 Antibody Blocking Peptide |
| 中文名称 | 叉头蛋白D3封闭多肽 |
| 英文别名 | AIS1; forkhead box D3; Forkhead box protein D3; FOXD3_HUMAN |
| 纯化方法 | HPLC |
| 研究领域 | Developmental Biology > Embryogenesis > Embryonic stem cells > Surface molecules Epigenetics and Nuclear Signaling > Transcription > Domain Families > Forkhead Box > FOXD Metabolism > Types of disease > Cancer Neuroscience > Neurology process > Metabolism Neuroscience > Neurology process > Neurogenesis Stem Cells > Embryonic Stem Cells > Intracellular Stem Cells > Neural Stem Cells > Intracellular |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. |
| 相似性 | Contains 1 fork-head DNA-binding domain. |
| 功能 | Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Embryonic stem cells require the forkhead transcriptional regulator FoxD3 for survival. Following gastrulation, FoxD3 generally gets downregulated, except in the neural crest. A variety of growth factors induce FoxD3 expression, including FGF8 and SNAIL, maintaining the effected cells in an undifferentiated state. Thus defects in FoxD3 induction may cause premature differentiation and/or migration-asociated birth defects. |
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FOXD3 Antibody Blocking Peptide(bs-11518P)-500ug
￥880
