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- Bioss
- bs-9224P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-9224P |
| 英文名称 | RNF41 Antibody Blocking Peptide |
| 中文名称 | 环指蛋白41封闭多肽 |
| 英文别名 | E3 ubiquitin protein ligase NRDP1; Fetal Liver RING finger protein; FLRF; MGC45228; Neuregulin receptor degradation protein 1; NRDP1; Ring Finger Protein 41; SBBI03; RNF41_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with USP8, ERBB3, PARK2 and BIRC6. Interacts with CSF2RB, EPOR, IL3RA, MYD88 and TBK1 (By similarity). |
| 组织特异性 | Detected in ovary, testis and prostate. |
| 翻译后修饰 | Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis. |
| 相似性 | Contains 1 RING-type zinc finger. Contains 1 SIAH-type zinc finger. |
| 功能 | Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | RNF41 contains one RING-type zinc finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. It acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins, such as ERBB3. RNF41 has been detected in ovary, testis and prostate. |
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RNF41 Antibody Blocking Peptide(bs-9224P)-500ug
￥880
