- ￥880
- Bioss
- bs-17018P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-17018P |
| 英文名称 | RNF213 Antibody Blocking Peptide |
| 中文名称 | KIAA1618蛋白封闭多肽 |
| 英文别名 | ALK lymphoma oligomerization partner on chromosome 17; ALO17; RN213_HUMAN; Hypothetical protein LOC57714; Protein ALO17. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Other Antibodies > Other Antibodies |
| 亚细胞定位 | Cytoplasm. |
| 组织特异性 | Widely expressed (at protein level). |
| 翻译后修饰 | Autoubiquitinates. |
| 相似性 | Contains 1 RING-type zinc finger. |
| 功能 | Probable E3 ubiquitin-protein ligase that may play a role in angiogenesis. May also have an ATPase activity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made up of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF213 (ring finger protein 213), also known as NET57, is a 3,280 amino acid protein containing one RING-type zinc finger domain through which it may play a role in transcriptional regulation and protein degradation. RNF213 is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. |
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RNF213 Antibody Blocking Peptide(bs-17018P)-500ug
￥880
