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- Bioss
- bs-7851P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-7851P |
| 英文名称 | KATNB1 Antibody Blocking Peptide |
| 中文名称 | 剑蛋白p80封闭多肽 |
| 英文别名 | KAT; Katanin (80 kDa); Katanin p80 (WD repeat containing) subunit B 1; Katanin p80 subunit B 1; Katanin p80 subunit B1; Katanin p80 WD40-containing subunit B1; katnb1; KTNB1_HUMAN; OTTHUMP00000164672; p80 katanin. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Cell Cycle > Cell Division > Spindle |
| 亚基 | Interacts with PAFAH1B1 (By similarity). Interacts withKATNA1. This interaction enhances the microtubule binding andsevering activity of KATNA1 and also targets this activity to thecentrosome. Interacts with dynein, microtubules and NDEL1. |
| 亚细胞定位 | Cytoplasm. Cytoplasm, cytoskeleton,centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm,cytoskeleton. Note=Predominantly cytoplasmic. Localized to theinterphase centrosome and mitotic spindle poles |
| 相似性 | Belongs to the WD repeat KATNB1 family. Contains 6 WD repeats. |
| 功能 | Participates in a complex which severs microtubules inan ATP-dependent manner. May act to target the enzymatic subunit ofthis complex to sites of action such as the centrosome. Microtubulesevering may promote rapid reorganization of cellular microtubulearrays and the release of microtubules from the centrosomefollowing nucleation. Microtubule release from the mitotic spindlepoles may allow depolymerization of the microtubule end proximal tothe spindle pole, leading to poleward microtubule flux and polewardmotion of chromosome. Microtubule release within the cell body ofneurons may be required for their transport into neuronal processesby microtubule-dependent motor proteins. This transport is requiredfor axonal growth (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Microtubules, polymers of alpha and beta tubulin subunits,form the mitotic spindle of a dividing cell and help to organizemembranous organelles during interphase. Katanin is a heterodimerthat consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDaaccessory protein (p80 subunit B 1). The p60 subunit acts to severand disassemble microtubules, while the p80 subunit targets theenzyme to the centrosome. Katanin is a member of the AAA family ofATPases. |
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KATNB1 Antibody Blocking Peptide(bs-7851P)-500ug
￥880
