- ￥880
- Bioss
- bs-9151P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-9151P |
| 英文名称 | TRIM41 Antibody Blocking Peptide |
| 中文名称 | 环指蛋白调节蛋白激酶C蛋白封闭多肽 |
| 英文别名 | RINCK; RING finger protein that interacts with C kinase; Trim41; Tripartite motif containing 41; TRI41_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > RING Finger E3 Ligase |
| 亚基 | Interacts with PRKCA. |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 组织特异性 | Expressed in multiple tissues with the highest levels in heart and skeletal muscle. |
| 翻译后修饰 | Auto-ubiquitinated. |
| 相似性 | Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 B30.2/SPRY domain. Contains 1 RING-type zinc finger. |
| 功能 | Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Tripartite motif-containing protein 41 (TRIM41), also known as RINCK, is a 630 amino acid member of the TRIM family, also known as the RING-B-box coiled-coil (RBCC) family. Members of the RBCC family have an N-terminal RING finger, followed by one or two zinc-binding domains (B-box domains), a leucine coiled-coil region and a variable C-terminal domain. Localized to both the nucleus and cytoplasm, TRIM41 associates with protein kinase C (PKC) through the C1A domain of PKC. Studies have shown that overexpression of TRIM41 reduces the levels of PKC in cells, whereas knockdown of TRIM41 leads to increased levels of PKC. Thus, it is hypothesized that TRIM41 plays a role in regulating PCK levels in cells, specifically through the ubiquitination of PKC. Four isoforms of TRIM41 exist as a result of alternative splicing events. |
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TRIM41 Antibody Blocking Peptide(bs-9151P)-500ug
￥880
