- ￥880
- Bioss
- bs-9126P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-9126P |
| 英文名称 | GPS1 Antibody Blocking Peptide |
| 中文名称 | G蛋白通路抑制蛋白1封闭多肽 |
| 英文别名 | Arabidopsis Fus6/Cop 11 homolog; Arabidopsis Fus6/Cop 11 homolog; constitutive photomorphogenic homolog subunit 1; constitutive photomorphogenic homolog subunit 1; COP9; COP9 signalosome complex subunit 1; COP9 signalosome complex subunit 1; COPS1; COPS1; CSN 1; CSN1_HUMAN; G protein pathway suppressor 1; G protein pathway suppressor 1; GPS-1; GPS1; GPS1; JAB1-containing signalosome subunit 1; MFH protein; MFH protein; Protein GPS1; Protein MFH; SGN1; Signalosome subunit 1; Y59A8A.1. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Proteasome Neuroscience > Neurotransmission > Intracellular Signaling > Kinases Neuroscience > Neurotransmission > Intracellular Signaling > Regulation Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases |
| 亚基 | Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS2, COPS3, COPS4 and CSN5. Interacts directly with inositol kinase ITPK1. Interacts with CAPN8 (By similarity). |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 组织特异性 | Widely expressed. |
| 翻译后修饰 | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the CSN1 family.
Contains 1 PCI domain. |
| 功能 | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction. |
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GPS1 Antibody Blocking Peptide(bs-9126P)-500ug
￥880
