- ￥880
- Bioss
- bs-11041P
- 2025年10月16日
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500ug
| 产品编号 | bs-11041P |
| 英文名称 | BEST2 Antibody Blocking Peptide |
| 中文名称 | 卵黄状黄斑病蛋白2封闭多肽 |
| 英文别名 | BEST 2; Best disease Bestrophin; BEST2; Bestrophin2; FLJ20132; Vitelliform macular dystrophy 2 homolog; Vitelliform macular dystrophy 2 like 1; Vitelliform macular dystrophy 2 like protein 1; Vitelliform macular dystrophy; VMD2; VMD2 like gene 1; VMD2L1; BEST2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Blood Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > NFkB pathway Immunology > Adaptive Immunity > B Cells > Non-CD Immunology > Immune System Diseases > Antiviral Signaling > HIV-related Signal Transduction > Signaling Pathway > Nuclear Signaling > NFkB Pathway Stem Cells > Hematopoietic Progenitors > Surface Molecules Tags & Cell Markers > Cell Type Markers > Other Cell Types |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Mainly confined to the retinal pigment epithelium and colon. |
| 相似性 | Belongs to the bestrophin family. |
| 功能 | Forms calcium-sensitive chloride channels. Permeable to bicarbonate. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), 1 also known as Best disease. Three more members of the bestrophin family members were cloned and indentified recently, Bestrophin 2, 3 and 4. RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac). Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac and the Bestrophin takes place near the carboxy terminal end of the protein. |
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BEST2 Antibody Blocking Peptide(bs-11041P)-500ug
￥880
