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- Bioss
- bs-9119P
- 2025年10月16日
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500ug
| 产品编号 | bs-9119P |
| 英文名称 | COPS8 Antibody Blocking Peptide |
| 中文名称 | 信号转导蛋白亚基8封闭多肽 |
| 英文别名 | COP9 homolog; COP9 signalosome complex subunit 8; Cops8; CSN8; CSN8_HUMAN; hCOP9; JAB1 containing signalosome subunit 8; JAB1-containing signalosome subunit 8; SGN8; Signalosome subunit 8. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Proteasome Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > SCF Complex E3 Ligase Developmental Biology > Reproduction > Germ cell markers Immunology > Adaptive Immunity > T Cells > Non-CD Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases Stem Cells > Germline Stem Cells > Embryonic Germ Cells |
| 亚基 | Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B). |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 相似性 | Belongs to the CSN8 family. Contains 1 PCI domain. |
| 功能 | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]. |
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COPS8 Antibody Blocking Peptide(bs-9119P)-500ug
￥880
