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- Bioss
- bs-20392P
- 2025年10月16日
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500ug
| 产品编号 | bs-20392P |
| 英文名称 | GP1BA Antibody Blocking Peptide |
| 中文名称 | 血小板糖蛋白GPIb封闭多肽 |
| 英文别名 | Antigen CD42b alpha; BSS; CD 42b; CD42b alpha; CD42b antigen; GLYCOCALICIN; Glycoprotein Ib (platelet) alpha polypeptide; Glycoprotein Ibalpha; GP Ib alpha; GP1B; GP1BA; GPIb alpha; MGC34595; Platelet glycoprotein Ib alpha chain; Platelet glycoprotein Ib alpha polypeptide; Platelet membrane glycoprotein 1b alpha subunit. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Blood > Platelets Immunology > Cell Type Markers > CD > Platelets |
| 亚基 | Heterodimer composed of GP-Ib alpha and beta; disulfide linked. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage. Interacts with FLNB. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 翻译后修饰 | lycocalicin, which is approximately coextensive with the extracellular part of the molecule, is cleaved off by calpain during platelet lysis. |
| 相似性 | Contains 7 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain. Contains 1 LRRNT domain. |
| 功能 | GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. [provided by RefSeq, Mar 2010]. |
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GP1BA Antibody Blocking Peptide(bs-20392P)-500ug
￥880
