- ￥880
- Bioss
- bs-7730P
- 2025年10月16日
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- 详细信息
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- 规格：
500ug
| 产品编号 | bs-7730P |
| 英文名称 | SMC6 Antibody Blocking Peptide |
| 中文名称 | 染色体结构维持蛋白6封闭多肽 |
| 英文别名 | SMC6L1; SMC 6; SMC6; SMC6 protein; SMC6 structural maintenance of chromosomes 6 like 1; Structural maintenance of chromosomes 6; Structural maintenance of chromosomes 6 like 1; Structural maintenance of chromosomes protein 6. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Cell Cycle > Cell Division > Chromatid Cohesion Epigenetics and Nuclear Signaling > Cell cycle > Chromosome Structure > Chromatid Cohesion |
| 亚基 | Forms a heterodimer with SMC5. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2. |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 组织特异性 | Widely expressed. Overexpressed in testis. |
| 翻译后修饰 | Ubiquitinated. |
| 相似性 | Belongs to the SMC family. SMC6 subfamily. |
| 功能 | Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SMC5/6 complex is recruited to nuclease induced double strand breaks (DSBs) and is required for the recruitment of cohesin to DSBs. The human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage induced apoptosis by facilitating DNA repair in human cells. |
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SMC6 Antibody Blocking Peptide(bs-7730P)-500ug
￥880
