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- 2025年10月16日
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500ug
| 产品编号 | bs-9044P |
| 英文名称 | TRPM7 Antibody Blocking Peptide |
| 中文名称 | 瞬时受体电位离子通道蛋白7封闭多肽（M亚家族） |
| 英文别名 | CHAK 1; CHAK; CHAK1; Channel kinase 1; Channel-kinase 1; FLJ20117; FLJ25718; homolog of mouse transient receptor potential-phospholipase C-interacting kinase; Long transient receptor potential channel 7; LTRPC 7; LTRPC ion channel family member 7; LTrpC-7; LTRPC7; transient receptor potential cation channel subfamily M member 7; TRP PLIK; TRP-PLIK; TRPM 7; TRPM7; TRPM7_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neurodegenerative disease > Amyotrophic lateral sclerosis Neuroscience > Neurology process > Neurodegenerative disease > Parkinson's disease Neuroscience > Neurotransmission > Intracellular Signaling > Kinases Neuroscience > Neurotransmission > Receptors / Channels > More Ion Channels |
| 亚基 | Homodimer. Interacts with PLCB1. Forms heterodimers with TRPM6. |
| 亚细胞定位 | Membrane; Multi-pass membrane protein |
| 翻译后修饰 | Autophosphorylated (By similarity). |
| 相似性 | In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7 sub-subfamily. Contains 1 alpha-type protein kinase domain. |
| 功能 | Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.[provided by RefSeq, May 2010]. |
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TRPM7 Antibody Blocking Peptide(bs-9044P)-500ug
￥880
