- ￥880
- Bioss
- bs-20307P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-20307P |
| 英文名称 | GSPT1 Antibody Blocking Peptide |
| 中文名称 | 真核肽链释放因子3a/eRF3封闭多肽 |
| 英文别名 | 551G9.2; Anti Eukaryotic Release Factor 3a; Anti G1 to S phase transition 1; Anti GST1, homolog of yeast; eRF 3a; eRF3a; G1 to S phase transition 1; G1 to S phase transition protein 1 homolog; G1 to S phase transition protein; GSPT 1; GSPT1; GST 1; GST1; GTP binding protein GST1 HS; Transition protein 1; ERF3A_MOUSE. |
| 纯化方法 | HPLC |
| 亚基 | Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. |
| 亚细胞定位 | Cytoplasmic. |
| 相似性 | Belongs to the GTP-binding elongation factor family. ERF3 subfamily. |
| 功能 | Translation termination in eukaryotes is governed by two proteins, belonging to the class-1 (eRF1) and class-2 (eRF3) polypeptide release factors. eRF3/GSPT1 is involved in regulation of mammalian cell growth and belongs to the GTP-binding elongation factor family (ERF3 subfamily). eRF3 catalyzes hydrolysis of GTP to GDP and inorganic phosphate in the ribosome in the absence of mRNA, tRNA, aminoacyl-tRNA and peptidyl-tRNA. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | eRF3a is a 499 amino acid protein that belongs to the GTP-binding elongation factor family and is involved in the regulation of cell growth, specifically via control of translation termination. Human eRF3a shares 94% sequence identity with its mouse counterpart, suggesting a conserved function between species. The gene encoding eRF3a maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition. |
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GSPT1 Antibody Blocking Peptide(bs-20307P)-500ug
￥880
