- ￥880
- Bioss
- bs-20241P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-20241P |
| 英文名称 | Musashi 1 Antibody Blocking Peptide |
| 中文名称 | 神经干细胞RNA结合蛋白Musashi1封闭多肽 |
| 英文别名 | Musashi 1 / Msi1; Msi 1; Msi1; Msi-1; MSI1H_HUMAN; Musashi homolog 1; Musashi-1; Musashi1; RNA binding protein Musashi homolog 1; RNA-binding protein Musashi homolog 1. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Type Marker > Neural Stem Cell marker Neuroscience > Neurology process > Neurogenesis Stem Cells > Neural Stem Cells > Glial Restricted Lineage > Astrocyte Stem Cells > Neural Stem Cells > Intracellular Stem Cells > Signaling Pathways > Notch > Cytoplasmic Stem Cells > Signaling Pathways > Notch > Nuclear |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 组织特异性 | Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines. |
| 相似性 | Belongs to the Musashi family.
Contains 2 RRM (RNA recognition motif) domains. |
| 功能 | RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Musashi1 (Msi1) is an RNA-binding protein expressed in neural progenitor cells and neural stem cells. Msi1 is the mammalian homolog of Drosophila Musashi. The gene encoding human Msi1 encodes a 362 amino acid protein. In murine embryonic neural progenitor cells, Msi1 localizes to the cytoplasm and is downregulated during differentiation. Msi1 binds to NUMB, which encodes a membrane-associated antagonist of Notch signaling. Msi1 appears to function in the proliferation and maintenance of stem cell populations of the central nervous system. In addition to its usefulness as a marker for neural progenitor cells in normal human brains, Msi1 is also a marker for human gliomas. In rats, Msi1 is expressed in Sertoli cells of the testis and granulosa cells of the ovary. |
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Musashi 1 Antibody Blocking Peptide(bs-20241P)-500ug
￥880
