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- Bioss
- bs-8929P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-8929P |
| 英文名称 | Cyclin E Antibody Blocking Peptide |
| 中文名称 | 周期素E1封闭多肽 |
| 英文别名 | CCNE 1; CCNE; CCNE1; Cyclin E1 antibody Cyclin Es; Cyclin Et; CyclinE; G1/S specific cyclin E; CCNE1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell cycle > Cyclins > Cyclin E family Cell Biology > Cell Cycle > Cyclins Cell Biology > Cell Cycle > Cyclins > Cyclin E Family Epigenetics and Nuclear Signaling > Cell cycle > Cyclins > Cyclin E Family |
| 亚基 | Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. |
| 翻译后修饰 | Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the cyclin family. Cyclin E subfamily. |
| 功能 | Essential for the control of the cell cycle at the G1/S (start) transition. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers. |
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Cyclin E Antibody Blocking Peptide(bs-8929P)-500ug
￥880
