- ￥880
- Bioss
- bs-20291P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-20291P |
| 英文名称 | ERRFI1 Antibody Blocking Peptide |
| 中文名称 | 有丝分裂原诱导基因6封闭多肽 |
| 英文别名 | ERBB receptor feedback inhibitor 1; GENE 33; MIG6; mitogen inducible gene 6; mitogen inducible gene 6 protein; RALT; receptor-associated late transducer; ERRFI_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | interacts with ERBB2. Interacts with EGFR. |
| 亚细胞定位 | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes. |
| 相似性 | Belongs to the MIG6 family. |
| 功能 | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | ERRFI1 belongs to a class of mammalian regulators of tyrosine kinase signalling, whose expression is trascriptionally controlled by receptor activation. A number of features reveal this protein as a canidate for being a signal transducing protein; proline rich sequences, consensus sequences for phosphorylation of ERK1 and ERK2, a potential binding site for 14-3-3 proteins and other potential sites for phosphorylation by protein kinase C, A and Casein kinase II. |
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ERRFI1 Antibody Blocking Peptide(bs-20291P)-500ug
￥880
