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- Bioss
- bs-20261P
- 2025年10月16日
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500ug
| 产品编号 | bs-20261P |
| 英文名称 | Phospho-CFL1 (Ser3) Antibody Blocking Peptide |
| 中文名称 | 磷酸化丝切蛋白(Ser3)封闭多肽 |
| 英文别名 | Cofilin (Phospho-Ser3); Cofilin (Phospho S3); Cofilin-1; 18 kDa phosphoprotein; CFL 1; CFL; CFL1; Cofilin 1; Cofilin 1 non muscle; Cofilin non muscle isoform; p18; COF1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Invasion/microenvironment > ECM > Cell adhesion Cardiovascular > Heart > Contractility > Contractile Proteins > Actins Cardiovascular > Vasculature > Smooth muscle cell (SMC) > Cytoskeleton Neuroscience > Cell Type Marker > Neuron marker > Axon marker Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Binding Proteins |
| 亚基 | Can bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is a major component of intranuclear and cytoplasmic actin rods. |
| 亚细胞定位 | Nucleus matrix. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide. |
| 组织特异性 | Widely distributed in various tissues. |
| 翻译后修饰 | Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal |
| 相似性 | Belongs to the actin-binding proteins ADF family. Contains 1 ADF-H domain. |
| 功能 | Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. |
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Phospho-CFL1 (Ser3) Antibody Blocking Peptide(bs-20261P)-500ug
￥1080
