- ￥880
- Bioss
- bs-20189P
- 2025年10月16日
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500ug
| 产品编号 | bs-20189P |
| 英文名称 | MCU Antibody Blocking Peptide |
| 中文名称 | 线粒体钙离子单向转运蛋白MCU封闭多肽 |
| 英文别名 | MCU_HUMAN; C10orf42; Ccdc109a; Coiled-coil domain-containing protein 109A; Mitochondrial Calcium Uniporter. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Heart > Cardiac metabolism Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers |
| 亚基 | Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1. Heterotetramer with CCDC109B/MCUB; this inhibits channel activity. Homotetramer. Interacts with MICU1; MICU1 acts as an essential regulator for MCU. Interacts with MCUR1; interaction with MICU1 and MCUR1 are mutually exclusive. |
| 亚细胞定位 | Membrane. |
| 相似性 | Belongs to the CCDC109 family. |
| 功能 | Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] |
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MCU Antibody Blocking Peptide(bs-20189P)-500ug
￥880
