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- Bioss
- bs-20110P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-20110P |
| 英文名称 | IPO8 Antibody Blocking Peptide |
| 中文名称 | Ran结合蛋白8封闭多肽 |
| 英文别名 | FLJ26580; Imp 8; Imp8; Importin-8; Importin8; IPO 8; IPO8; IPO8_HUMAN; Ran binding protein 8; RAN BP8; Ran-binding protein 8; RANBP 8; RANBP8. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Nuclear Pore Complex Signal Transduction > Protein Trafficking > Nuclear Import / Export |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 相似性 | Belongs to the importin beta family.
Contains 1 importin N-terminal domain. |
| 功能 | Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] |
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IPO8 Antibody Blocking Peptide(bs-20110P)-500ug
￥880
