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- Bioss
- bs-11237P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-11237P |
| 英文名称 | TCF12 Antibody Blocking Peptide |
| 中文名称 | 转录因子12封闭多肽 |
| 英文别名 | bHLHb20; Class B basic helix-loop-helix protein 20; DNA binding protein HTF4; DNA-binding protein HTF4; E box binding protein; E-box-binding protein; HEB; HTF4; HTF4_HUMAN; TCF-12; Tcf12; Transcription factor 12; Transcription factor HTF-4; Transcription factor HTF4. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > HLH Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription |
| 亚基 | Binds specifically to oligomers of E-box motifs. May play important roles during development of the nervous system as well as in other organ systems. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Expressed in several tissues and cell types including skeletal muscle, thymus, and a B-cell line. |
| 相似性 | Contains 1 bHLH (basic helix-loop-helix) domain. |
| 功能 | Binds specifically to oligomers of E-box motifs. May play important roles during development of the nervous system as well as in other organ systems. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes. Both homo- and hetero-oligomers of these proteins are able to distinguish very closely related E box proteins and are believed to play important roles in lineage specific gene expression. |
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TCF12 Antibody Blocking Peptide(bs-11237P)-500ug
￥880
