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- bs-9219P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-9219P |
| 英文名称 | RNF157 Antibody Blocking Peptide |
| 中文名称 | 1号染色体开放阅读框149封闭多肽 |
| 英文别名 | CDABP0189; Chromosome 1 open reading frame 149; Eaf6; FLJ11730; Hypothetical protein LOC64769; NY SAR 91; RP3 423B22.2; Sarcoma antigen NY SAR 91; EAF6_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5 and the subunits EP400, TRRAP, BRD8, EPC1, DMAP1, RUVBL1, RUVBL2, ING3, actin, ACTL6A, MORF4L1, MORF4L2, MRGBP, YEATS4, VPS72 and MEAF6. Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16 and PHF17. Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. |
| 亚细胞定位 | Nucleus; nucleolus |
| 翻译后修饰 | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the EAF6 family. |
| 功能 | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | MEAF6, also known as Eaf6 or NY-SAR-91, is a 191 amino acid nuclear protein belonging to the EAF6 family. MEAF6 is a component of the NuA4 histone acetyltransferase complex, which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. The gene encoding MEAF6 localizes to chromosome 1 and, due to alternative splicing events, MEAF6 exists in at least three isoforms. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1 such as Hutchinson-Gilford progeria, Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome. |
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RNF157 Antibody Blocking Peptide(bs-9219P)-500ug
￥880
