- ￥880
- Bioss
- bs-7974P
- 2025年10月16日
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500ug
| 产品编号 | bs-7974P |
| 英文名称 | ATX2 Antibody Blocking Peptide |
| 中文名称 | 脊髓小脑共济失调2型蛋白封闭多肽 |
| 英文别名 | Ataxin 2; ATXN2; Olivopontocerebellar ataxia 2, autosomal dominant; SCA2; Spinocerebellar ataxia type 2 protein; TNRC13; Trinucleotide repeat containing gene 13 protein; SRRT_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Other Antibodies > Other Antibodies Epigenetics and Nuclear Signaling > DNA / RNA > Translation > Regulation Neuroscience > Neurology process > Neurodegenerative disease |
| 亚基 | Monomer. Can also form homodimers. |
| 亚细胞定位 | Cytoplasm. |
| 组织特异性 | Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus. |
| 相似性 | Belongs to the ataxin-2 family. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ATX2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. ATX2 is caused by expansion of a CAG repeat in the coding region of ATX2. Longer expansions result in earlier onset of the disease. There are four named isoforms. |
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ATX2 Antibody Blocking Peptide(bs-7974P)-500ug
￥880
