- ￥880
- Bioss
- bs-11204P
- 2025年10月16日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11204P |
| 英文名称 | PAX6 Antibody Blocking Peptide |
| 中文名称 | 转录因子Pax6封闭多肽 |
| 英文别名 | AN 2; AN antibody; AN2; Aniridia type II protein; D11S812E; MGC17209; MGDA; Oculorhombin; Paired box 6; Paired box gene 6 (aniridia keratitis); Paired Box Gene 6; Paired box homeotic gene 6; Paired box protein Pax-6; Paired box protein PAX 6; PAX6; PAX6_HUMAN; Sey; WAGR. |
| 纯化方法 | HPLC |
| 研究领域 | Developmental Biology > Lineage specification > Ectoderm Developmental Biology > Lineage specification > Endoderm Developmental Biology > Organogenesis > Gut development > Pancreas development Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families > PAX Neuroscience > Cell Type Marker > Neural Stem Cell marker Neuroscience > Neurology process > Neural Signal Transduction Stem Cells > Lineage Markers > Ectoderm Stem Cells > Lineage Markers > Endoderm |
| 亚基 | Interacts with MAF and MAFB (By similarity). Interacts with TRIM11; this interaction leads to ubiquitination and proteasomal degradation, as well as inhibition of transactivation, possibly in part by preventing PAX6 binding to consensus DNA sequences. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form. |
| 翻译后修饰 | Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation. |
| 相似性 | Belongs to the paired homeobox family.
Contains 1 homeobox DNA-binding domain. Contains 1 paired domain. |
| 功能 | Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Pax genes contain paired domains with strong homology to genes in Drosophila which are involved in programming early development. The PAX2 gene is expressed in primitive cells of the kidney, ureter, eye, ear, and central nervous system. More specifically, in human embryo sections, PAX2 is expressed in the optic vesicle and later in the retina, in the otic vesicle and later in the semicircular canals of the inner ear, and in mesonephros, metanephros, adrenals, spinal cord, and hindbrain. PAX2 mutations can be responsible for renal hypoplasia, either isolated or associated with various ophthalmologic manifestations ranging from retinal coloboma to microphthalmia. The gene which encodes Pax-2 maps to human chromosome 10q24.3-q25.1. Lesions in the PAX6 gene accounts for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. PAX6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The gene which encodes Pax-6 maps to human chromosome 11p13. |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
PAX6 Antibody Blocking Peptide(bs-11204P)-500ug
￥880
