- ￥880
- Bioss
- bs-11198P
- 2025年10月16日
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500ug
| 产品编号 | bs-11198P |
| 英文名称 | ProSAPiP1 Antibody Blocking Peptide |
| 中文名称 | 含脯氨酸突触相关蛋白相互作用蛋白1封闭多肽 |
| 英文别名 | KIAA0552; PRIP1_HUMAN; Proline rich synapse associated protein interacting protein 1; ProSAP-interacting protein 1; ProSAPiP1; ProSAPiP1 protein. |
| 纯化方法 | HPLC |
| 亚基 | Interacts (via C-terminus) with SHANK3 (via PDZ domain). Interacts (via coiled coil) with SIPA1L1. Can form homooligomers (By similarity). |
| 亚细胞定位 | Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cytoplasm > cytoskeleton. Detected at synapses, postsynaptic density, synaptic spines and dendrites. |
| 相似性 | Belongs to the PROSAPIP1 family. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The ProSAP family of proteins contain many protein-protein interaction domains and serve as scaffolding mediators within the post-synaptic density (PSD) of excitatory brain synapses. The PSD is an electron-dense structure underneath the post-synaptic plasma membrane of excitatory synapses that anchors and clusters glutamate receptors opposite to the pre-synaptic neurotransmitter release site. Shank proteins contain PDZ modular domains that coordinate the synaptic localization of ion channels, receptors, signaling enzymes, and cell adhesion molecules. The PDZ domain mediates protein-protein interactions via the recognition of a conserved sequence motif at the C-terminus of their target protein(s). ProSAPiP1 (proline rich synapse associated protein interacting protein 1) is a 673 amino acid protein that interacts with the PDZ domain of Shank 3. ProSAPiP1 expression is brain-specific with highest expression within the cerebellum, hippocampus and cerebral cortex. |
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ProSAPiP1 Antibody Blocking Peptide(bs-11198P)-500ug
￥880
