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- 2025年10月16日
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500ug
| 产品编号 | bs-17643P |
| 英文名称 | SPCS3 Antibody Blocking Peptide |
| 中文名称 | 信号肽复合物亚基3封闭多肽 |
| 英文别名 | DKFZp564J1864; FLJ22649; Microsomal signal peptidase 22/23 kDa subunit; Microsomal signal peptidase 23 kDa subunit; PRO3567; Signal peptidase complex subunit 3; Signal peptidase complex subunit 3 homolog (S. cerevisiae); Signal peptidase complex subunit 3 homolog; SPase 22 kDa subunit; SPase 22/23 kDa subunit; SPC22; SPC22/23; SPC3; UNQ1841; YLR066W. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > Translation > ER Translocation Signal Transduction > Protein Trafficking > ER Proteins |
| 亚基 | Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3. |
| 亚细胞定位 | Endoplasmic reticulum and Microsome membrane;: Single-pass type II membrane protein |
| 相似性 | Belongs to the SPCS3 family. |
| 功能 | A component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SPCS3 (signal peptidase complex subunit 3), also known as SPC3, is a 180 amino acid single-pass type II membrane protein that localizes to both the microsome and the endoplasmic reticulum (ER) and belongs to the SPCS (signal peptidase complex subunit) family. Existing as a component of the microsomal signal peptidase complex which consists of five members, SPCS3 functions to remove signal peptides from proteins that are translated to the lumen of the ER. The gene encoding SPCS3 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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