- ￥880
- Bioss
- bs-7735P
- 2025年10月16日
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500ug
| 产品编号 | bs-7735P |
| 英文名称 | STAMBP Antibody Blocking Peptide |
| 中文名称 | 信号转导衔接结合蛋白封闭多肽 |
| 英文别名 | AMSH; Associated molecule with the SH3 domain of STAM; Endosome associated ubiquitin isopeptidase; Endosome-associated ubiquitin isopeptidase; STABP_HUMAN; STAM binding protein; STAM-binding protein; STAMBP. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Cell Cycle > Cell Division > Cytokinesis Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Deubiquitination Epigenetics and Nuclear Signaling > Ubiquitin & Ubiquitin Like Modifiers > Deubiquitination |
| 亚细胞定位 | Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome. |
| 组织特异性 | Ubiquitously expressed. |
| 翻译后修饰 | Phosphorylated after BMP type I receptor activation. Ubiquitinated by SMURF2 in the presence of RNF11. |
| 相似性 | Belongs to the peptidase M67C family. Contains 1 MPN (JAB/Mov34) domain. |
| 功能 | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. |
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STAMBP Antibody Blocking Peptide(bs-7735P)-500ug
￥880
