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- 详细信息
- 技术资料
- 规格:
500ug
| 产品编号 | bs-12494P |
| 英文名称 | APOBEC3B Antibody Blocking Peptide |
| 中文名称 | 载脂蛋白B-mRNA编辑酶复合物3B封闭多肽 |
| 英文别名 | APOBEC1L; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3B; apolipoprotein B mRNA editing enzyme, catalytic;ARCD3; ARP4; bK150C2.2; Cytidine deaminase; DJ742C19.2; FLJ21201; Phorbolin 1 related protein; Phorbolin 2; Phorbolin 2/3; Phorbolin 3; PHRBNL; Probable DNA dC>dU editing enzyme APOBEC3B. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Binding Proteins > DNA / RNA binding Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Deamination Immunology > Immune System Diseases > Antiviral Signaling |
| 亚基 | Homodimer. Interacts with APOBEC3G. Does not interact with APOBEC1. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart, thymus, prostate and ovary. Also expressed at low levels in several other tissues. |
| 相似性 | It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Belongs to the cytidine and deoxycytidylate deaminase family. Contains 2 CMP/dCMP deaminase zinc-binding domains |
| 功能 | APOBEC3B is a member of the cytidine deaminase gene family. However, it lacks cytidine deaminase activity, at least on RNA molecules (monomeric nucleoside substrates or synthetic apoB, NF1 and NAT1 RNA template). It binds to apoB and AU-rich RNAs. It is unable to reduce HIV-1 infectivity in vitro. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | APOBEC proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. APOBEC3 proteins are thought to be RNA editing enzymes and have roles in cell growth. APOBEC3B, also known as phorbolin-1-related protein or phorbolin-2/3, is a 382 amino acid protein belonging to the cytidine and deoxycytidylate deaminase family. APOBEC3B lacks cytidine deaminase activity on RNA molecules, but has been shown to bind to apoB and AU-rich RNAs. APOBEC3B forms a homodimer and interacts with APOBEC3G. APOBEC3B is expressed at at moderate levels in heart, testis, thymus, prostate, ovary, spleen and peripheral blood leukocytes. |
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APOBEC3B Antibody Blocking Peptide(bs-12494P)-500ug
¥880





