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- bs-3458P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-3458P |
| 英文名称 | Phospho-TNNI3 (Ser23/24) Antibody Blocking Peptide |
| 中文名称 | 磷酸化钙调节蛋白-1封闭多肽 |
| 英文别名 | cardiac Troponin I (phospho S23 + S24); cardiac Troponin I (phospho Ser23 + Ser24); Phospho-Troponin I(Ser23/24); P-Troponin I(Ser23/24); troponin I type 3 (cardiac); cardiac muscle; Cardiac troponin I; Cardiomyopathy, familial hypertrophic, 7, included; CMD1FF; CMD2A; CMH7; cTnI; Familial hypertrophic cardiomyopathy 7; MGC116817; RCM1; Tn1; Tni; TNN I3; TNNC 1; TNNC1; TNNI3; TNNI3_HUMAN; Troponin I; Troponin I cardiac; Troponin I cardiac muscle; Troponin I cardiac muscle isoform; Troponin I type 3 cardiac; troponin I, cardiac 3; TroponinI. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Heart > Contractility > Contractile Proteins > Troponin Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Troponin |
| 亚基 | Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1. |
| 翻译后修饰 | Phosphorylated at Ser-42 and Ser-44 by PRKCE; phosphorylation increases myocardium contractile dysfunction. Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). |
| 相似性 | Belongs to the troponin I family. |
| 功能 | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008] |
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Phospho-TNNI3 (Ser23/24) Antibody Blocking Peptide(bs-3458P)-500ug
￥1080
