NUDCD3 Antibody Blocking Peptide(bs-13766P)-500ug

NUDCD3 Antibody Blocking Pepti

de(bs-13766P)-500ug
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  • ¥880
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  • bs-13766P
  • 2025年10月16日
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    • 规格

      500ug

    产品编号bs-13766P
    英文名称NUDCD3 Antibody Blocking Peptide
    中文名称NUDCD3蛋白封闭多肽
    英文别名KIAA1068; NudC domain containing 3; NudC domain containing protein 3; NudC like protein; NUDCD 3; NudCL; OTTHUMP00000159457; NUDC3_HUMAN; NudC domain-containing protein 3. .
    纯化方法HPLC
    研究领域

    Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Motor Proteins > Dynein

    相似性Contains 1 CS domain.
    功能NUDCD3 functions to maintain the stability of dynein intermediate chain. Depletion of NUDCD3 results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. NUDCD3 levels increase after the G1/S transition.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Nuclear migration is essential for growth, development and cellular function of multicellular organisms. NUDCD3 (NudC domain containing 3) is a 361 amino acid protein that contains one CS domain and is phosphorylated upon DNA damage by either ATR or ATM. Ubiquitously expressed, NUDCD3 has been observed to colocalize with Golgi marker proteins during interphase of mitosis in HeLa cells, and is found at low levels in brain, ovary and heart. The gene encoding NUDCD3 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.

     

     

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