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- bs-1046P
- 2025年10月16日
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500ug
| 产品编号 | bs-1046P |
| 英文名称 | CCL4 Antibody Blocking Peptide |
| 中文名称 | 巨噬细胞炎症因子1β /MIP-1β封闭多肽 |
| 英文别名 | MIP-1 Beta; macrophage inflammatory protein 1 Beta; MIP 1 beta; Secreted protein G 26; ACT 2; ACT2; AT744.1; CC chemokine ligand 4; CCL4; ccl4l 1; CCL4L1; Chemokine CC Motif Ligand 4; G 26 T lymphocyte secreted protein; HC21; LAG 1; LAG1; Lymphocyte activation gene 1; Lymphocyte activation gene 1 protein; Macrophage inflammatory protein 1 beta; MGC104418; MGC126025; MGC126026; MIP1 beta; MIP1B; MIP1B1; PAT 744; Protein H400; SCYA2; SCYA4; Secreted protein G26; SIS gamma; Small inducible cytokine A4; T cell activation protein 2; CCL4_MOUSE; |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Immune System Diseases > Antiviral Signaling > HIV-related Immunology > Innate Immunity > Chemokines > Beta Chemokines (CC) Immunology > Innate Immunity > Macrophage / Inflamm. Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Cytokines and cytokine receptors ELISA kits |
| 亚基 | Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69). |
| 亚细胞定位 | Secreted. |
| 翻译后修饰 | N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes. |
| 相似性 | Belongs to the intercrine beta (chemokine CC) family. |
| 功能 | Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | MIP1 alpha and MIP1 beta were originally co-purified from medium conditioned by an LPS-stimulated murine macrophage cell line. Human MIP1 beta refers to the products of several independently cloned cDNAs, including Act2, PAT 744, hH400, G26, HIMAP, HC21, and MAD 5a. The predicted protein products of these cDNAs represent variants that are between 94% - 98% identical and these proteins are all approximately 75% homologous to murine MIP1 beta. MIP1 beta also shares approximately 70% amino acid identity with MIP1 alpha. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation. The MIP1 proteins have chemoattractant and adhesive effects on lymphocytes, with MIP1 alpha and MIP1 beta preferentially attracting CD8+ and CD4+ T cells, respectively. A signal transducing receptor designated the CC chemokine receptor 1 (CC CKR1) with seven transmembrane domains that binds MIP1 alpha, MIP1 beta, MCP1 and RANTES with varying affinities has been isolated. |
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CCL4 Antibody Blocking Peptide(bs-1046P)-500ug
￥880
