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- Bioss
- bs-20494P
- 2025年10月16日
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500ug
| 产品编号 | bs-20494P |
| 英文名称 | Caspase-4 subunit p10 Antibody Blocking Peptide |
| 中文名称 | 半胱胺酸蛋白酶蛋白-4封闭多肽 |
| 英文别名 | Caspase-4 subunit 2; Caspase-4 subunit p10; Apoptosis related cysteine peptidase; Apoptotic cysteine protease Mih1/TX; CASP 4; CASP 4; CASP-4; CASP4; CASP4_HUMAN; CASP4_MOUSE; Caspase 4 apoptosis related cysteine peptidase; Caspase-4 subunit 2; Caspase4; ICE(rel) II; ICE(rel)-II; ICE(rel)II; ICEREL II; ICERELII; ICH 2; ICH 2 protease; ICH2; Mih1/TX; Mih1/TX; Protease ICH-2; Protease TX; TX; TX protease. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Apoptosis > Intracellular > Caspases etc > Caspases |
| 亚基 | Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit. |
| 组织特异性 | Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain. |
| 翻译后修饰 | The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8. |
| 相似性 | Belongs to the peptidase C14A family. Contains 1 CARD domain. |
| 功能 | Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Caspase 4 is a 377 amino acid protein (43 kDa) that belongs to the Ced3/ICE family of cystein proteases. Caspase 4 is an "upstream" caspase with a long prodomain. It undergoes a cleavage upon activation, leading to p20 and p10 subunits which have 67% homology to mature Caspase 1 over the equivalent coding sequences. Caspase 4 is capable of cleaving itself and the p30 Caspase 1 precursor, and of inducing apoptosis in transfected insect or COS cells. In high concentrations, it can also cleave the nuclear DNA enzyme PARP but the biological relevance of this cleavage is unclear. Caspase 4 mRNA is found in most tissues examined with the exception of the brain. Highest expression is found in spleen and lung, with moderate expression in heart and liver. Low expression is observed with skeletal muscle, kidney, and testis. |
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Caspase-4 subunit p10 Antibody Blocking Peptide(bs-20494P)-500ug
￥880
