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- bs-2365P
- 2025年10月16日
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500ug
| 产品编号 | bs-2365P |
| 英文名称 | Eppin Antibody Blocking Peptide |
| 中文名称 | 附睾蛋白酶抑制蛋白封闭多肽+O13844 |
| 英文别名 | SPINLW1; WAP7; WFDC7; Variant; Cancer/testis antigen 71; CT71; Epididymal protease inhibitor; Protease inhibitor WAP7; Serine protease inhibitor-like with Kunitz and WAP domains 1; EPPI_MOUSE; WAPfour-disulfide core domain protein 7. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Protease inhibitors > Other protease inhibitors |
| 亚基 | Monomer (By similarity). Homodimer (By similarity). Homomultimers (By similarity). Interacts (via C-terminus) with SEMG1 (via 164-283 AA) (By similarity). Interacts with LTF (By similarity). Found in a complex with LTF, CLU, EPPIN and SEMG1 (By similarity). |
| 亚细胞定位 | Secreted. Cell surface. Note=Present on the surface of spermatozoa both before and after capacitation. |
| 组织特异性 | Expressed in differentiated spermatogonia in testis. Expressed in spermatogonia cell lines GC-1 spg and GC-2spd(ts) as well as in the Leydig tumor cell line MLTC-1 (at protein level). Expressed specifically in epididymis and testis. Expressed predominantly on the postacrosomal region of mouse spermatozoa, in Sertoli cells, Leydig cells, and round spermatids in the testis, and in the principal cells of the cauda epididymidis epithelium. |
| 相似性 | Contains 1 BPTI/Kunitz inhibitor domain. Contains 1 WAP domain. |
| 功能 | Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. [provided by RefSeq]. |
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Eppin Antibody Blocking Peptide(bs-2365P)-500ug
￥880
