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- bs-1655P
- 2025年10月16日
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500ug
| 产品编号 | bs-1655P |
| 英文名称 | phospho-PAK3 (p-Ser139) Antibody Blocking Peptide |
| 中文名称 | 磷酸化p21激活激酶3封闭多肽 |
| 英文别名 | PAK3 (phospho S139); p-PAK3 (phospho S139); Beta PAK; bPAK; CDKN1A; hPAK3; Mental retardation X linked 30; MRX30; MRX47; Oligophrenin 3; OPHN3; p21 (CDKN1A) activated kinase 3; p21 activated kinase 3; p21 CDKN1A activated kinase 3; P21 protein (Cdc42/Rac) activated kinase 3; PAK-3; PAK3 p21 protein (Cdc42/Rac)-activated kinase 3; PAK3beta; Pak65alpha; Pak65beta; Serine threonine protein kinase PAK 3; Stk4. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Signal transduction > Protein phosphorylation > Serine/threonine kinases Cell Biology > Apoptosis > Intracellular > Kinases Microbiology > Interspecies Interaction > Host Virus Interaction Neuroscience > Neurology process > Neural Signal Transduction Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases Signal Transduction > Signaling Pathway > G Protein Signaling > Small G Proteins Signal Transduction > Signaling Pathway > G Protein Signaling > Small G Proteins > Ras Family |
| 亚基 | Interacts with HDAC1; the interaction is prevented by competitive binding of C10orf90/FATS to HDAC1 facilitating acetylation and protein stabilization of CDKN1A/p21 (By similarity). Interacts with MKRN1. Interacts with PSMA3. Interacts with PCNA. Component of the ternary complex, cyclin D-CDK4-CDKN1A. Interacts (via its N-terminal domain) with CDK4; the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and promotes the cyclin D-dependent enzyme activity of CDK4. Binding to CDK2 leads to CDK2/cyclin E inactivation at the G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S transition during DNA repair. Interacts with PIM1. |
| 亚细胞定位 | Cytoplasm. Nucleus |
| 组织特异性 | Expressed in all adult tissues, with 5-fold lower levels observed in the brain. |
| 翻译后修饰 | Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA. Phosphorylation at Ser-114 by GSK3-beta enhances ubiquitination by the DCX(DTL) complex. Phosphorylation of Thr-145 by PIM2 enhances CDKN1A stability and inhibits cell proliferation. Phosphorylation of Thr-145 by PIM1 results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. |
| 相似性 | Belongs to the CDI family. |
| 功能 | May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex . |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017] |
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phospho-PAK3 (p-Ser139) Antibody Blocking Peptide(bs-1655P)-500ug
￥1080
