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- bs-1158PC
- 2025年10月16日
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10mg/50mg
| 规格： | 10mg | 产品价格： | ￥980.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥3200.0 |
| 产品编号 | bs-1158PC |
| 英文名称 | AGEs (control article) |
| 中文名称 | 晚期糖基化终末产物蛋白对照品 |
| 英文别名 | advanced glycosylation end products control article; Advanced glycation end-products |
| 性状 | Lyophilized |
| 储存液 | PBS (pH=7.4). |
| 研究领域 | Cardiovascular > Blood > Serum Proteins Developmental Biology > Lineage specification > Endoderm Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Signal transduction proteins ELISA kits Metabolism > Types of disease > Metabolic disorders Signal Transduction > Metabolism > Lipid metabolism Signal Transduction > Protein Trafficking > Chaperones > Other Chaperones Stem Cells > Lineage Markers > Endoderm |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Plasma. |
| 翻译后修饰 | Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606. Glycated in diabetic patients. Phosphorylation sites are present in the extracelllular medium. Acetylated on Lys-223 by acetylsalicylic acid. |
| 相似性 | Belongs to the ALB/AFP/VDB family. Contains 3 albumin domains. |
| 功能 | Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes the most abundant protein in human blood. This protein functions in the regulation of blood plasma colloid osmotic pressure and acts as a carrier protein for a wide range of endogenous molecules including hormones, fatty acids, and metabolites, as well as exogenous drugs. Additionally, this protein exhibits an esterase-like activity with broad substrate specificity. The encoded preproprotein is proteolytically processed to generate the mature protein. A peptide derived from this protein, EPI-X4, is an endogenous inhibitor of the CXCR4 chemokine receptor. [provided by RefSeq, Jul 2016] |
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文献和实验[IF={{ 3.8 }}] {He Xingmin. et al. Cathepsin D inhibits AGEs-induced phenotypic transformation in vascular smooth muscle cells. SCI REP-UK. 2025 Apr;15(1):1-16} {} {}
[IF={{ 2.8 }}] {Rong Liu. et al. Advanced glycation end products promote the release of endothelial cell-derived mitocytosis. FEBS OPEN BIO. 2025 Apr;:} {} {}
[IF={{ 2.548 }}] {Zhang P et al. AGEs induce epithelial to mesenchymal transformation of human peritoneal mesothelial cells via upregulation of STAT3.Glycoconj J. 2019 Apr;36(2):155-163.} {Other} {}
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