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- Bioss
- bs-13694P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-13694P |
| 英文名称 | NOSTRIN Antibody Blocking Peptide |
| 中文名称 | 一氧化氮合酶转运诱导封闭多肽 |
| 英文别名 | BM247; BM247 homolog; DaIP2; eNOS-trafficking inducer; mDaIP2; MGC20702; Nitric oxide synthase traffic inducer; Nitric oxide synthase trafficker; NOSTN_HUMAN; Nostrin; RP23-431D4.2 |
| 纯化方法 | HPLC |
| 亚细胞定位 | Cell membrane. Cytoplasmic vesicle. Cytoplasm > cytoskeleton. Enriched in selected actin structures. |
| 组织特异性 | Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level). |
| 相似性 | Contains 1 FCH domain. Contains 1 SH3 domain. |
| 功能 | Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | NOSTRIN (nitric oxide synthase trafficker isoform 1), also known as endothelial nitric oxide synthase traffic inducer, is a member of the Pombe Cdc15 homology (PCH) family of proteins. NOSTRIN is expressed in the vascular endothelial cells of highly vascularized tissues such as placenta, lung, kidney and heart. It consists of an N-terminal Cdc15 domain with an FCH (Fes/CIP homology) region, two coiled coil domains and a C-terminal SH3 domain. NOSTRIN typically exists as a trimer. It functions as an adaptor protein binding to caveolin-1 via an internal domain and NOS3 via its SH3 domain, forming a ternary complex which facilitates caveolar transport of NOS3. The NOS3 protein is responsible for the production of nitric oxide (NO), a potent mediator in various biological processes. The translocation of NOS3 from the plasma membrane to intracellular vesicle-like structures diminishes NO production. NOSTRIN also interacts with Dynamin and N-WASP via its SH3 domain. |
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NOSTRIN Antibody Blocking Peptide(bs-13694P)-500ug
￥880
