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500ug
| 产品编号 | bs-15968P |
| 英文名称 | phospho-alpha Adducin (Ser436) Antibody Blocking Peptide |
| 中文名称 | 磷酸化内收蛋白a1封闭多肽 |
| 英文别名 | alpha Adducin(phospho S436); alpha Adducin(phospho Ser436); p-alpha Adducin(S436); p-alpha Adducin(Ser436); ADD 1; ADD A; ADD1; ADD1 protein; ADDA; ADDA_HUMAN; Adducin 1 (alpha); Adducin 1 alpha; Alpha adducin; Alpha-adducin; Erythrocyte adducin alpha subunit; Erythrocyte hosphor subunit alpha; Erythrocyte adducin subunit alpha. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > PKA Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > PKC Signal Transduction > Signaling Pathway > Calcium Signaling > Calmodulin Pathway Tags & Cell Markers > Subcellular Markers > Cytoskeleton > Actin |
| 亚基 | Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit. |
| 亚细胞定位 | Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
| 组织特异性 | Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit. |
| 相似性 | Belongs to the aldolase class II family. Adducin subfamily. |
| 功能 | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Adducins are a family of cytoskeleton proteins encoded by three genes (Alpha, Beta, Gamma). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical actin network organization. Adducin Alpha is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin Alpha and Adducin Gamma is ubiquitous in contrast to the restricted expression of Adducin Beta. Adducin Beta is expressed at high levels in brain and hematopoietic tissues, such as bone marrow, in humans, and in spleen in mice. |
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文献和实验Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
Antigen Design Sera Purification Tech Sheet
determination, protein homology studies and protein purification. While it is quite easy to generate anti-peptide antibodies, it is important to carefully consider the ultimate use for the antibody and the sequence used to ensure success. This tech sheet
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