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10mg/100mg/250mg
| 规格： | 10mg | 产品价格： | ￥240.0 |
|---|---|---|---|
| 规格： | 100mg | 产品价格： | ￥1200.0 |
| 规格： | 250mg | 产品价格： | ￥2400.0 |
| 产品编号 | bs-1240P |
| 英文名称 | Human Fibrinogen (from plasma) |
| 中文名称 | 人纤维蛋白原（进口） |
| 英文别名 | Factor I; FGA; FGA protein; FGB; FGG; Fib2; Fibrinogen A alpha polypeptide; Fibrinogen A alpha polypeptide chain; Fibrinogen alpha chain; Fibrinogen B alpha polypeptide; Fibrinogen beta chain; Fibrinogen G alpha polypeptide; Fibrinogen gamma chain; MGC104327; MGC119422; MGC119423; MGC119425; MGC120405; FIBRINOGEN, HUMAN TYPE I FROM HUMAN PLAS; Fibrinogen from human plasma (Native) |
| 中文别名 | 纤维蛋白原 来源于人类血浆; |
| 性状 | Lyophilized |
| 研究领域 | Cardiovascular > Atherosclerosis > Thrombosis Cardiovascular > Blood > Coagulation > Common Cardiovascular > Blood > Platelets Metabolism > Types of disease > Metabolic disorders |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Plasma. |
| 翻译后修饰 | The alpha chain is not glycosylated. Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers. About one-third of the alpha chains in the molecules in blood were found to be phosphorylated. Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Phosphorylation sites are present in the extracellular medium. |
| 相似性 | Contains 1 fibrinogen C-terminal domain. |
| 功能 | Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases. |
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文献和实验[IF={{ 3.55 }}] {Huang, Mo, et al. "Solidified liquid layer model makes quartz crystal microbalance a convenient molecular ruler." Colloids and Surfaces B: Biointerfaces 85.1 (2011): 92-96.} {Other} {=""}
concentration of purified thrombin. Plasma samples are pre-diluted which minimize assay interference from substances like heparin and fibrinogen degradation products. In brief, the diluted plasma is incubated at 37�C prior to the addition of the pre-warmed (37�C
Purification of Fibronectin from Human Plasma
for each cell and tissue. Although blood cells, such as lymphocytes, myelocytes, and erythrocytes, lack fibronectin, this gly-coprotein is abundant in the plasma (about 30 mg/100 mL). Actually, this body fluid represents the main source for fibronectin
Isolation of LDL(Low Density Lipoprotein) From Human Plasma:
This procedure involves use of human plasma, a potentially dangerous source of blood-borne disease. Wear long-cuffed gloves, and eye-protection. Day one: -Human Plasma is purchased from the Red-Cross. It should be 3-4 days old
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