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- bs-23548P
- 2025年10月16日
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500ug
| 产品编号 | bs-23548P |
| 英文名称 | ELANE Antibody Blocking Peptide |
| 中文名称 | 中性粒细胞弹性蛋白酶ELANE封闭多肽 |
| 英文别名 | Bone Marrow Serine Protease; ELA 2; ELA2; ELANE; Elastase 2; Elastase-2; Elastase 2 neutrophil; Elastase neutrophil expressed; Elastase-2; ELNE_HUMAN; GE antibody Granulocyte derived elastase; HLE; HNE; Human leukocyte elastase; Leukocyte elastase; Leukocyte Elastase Precursor; Medullasin; NE; Neutrophil elastase; Neutrophill elastase; PMN E; PMN Elastase; Polymorphonuclear elastase; SCN1; Serine protease; SERP1. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Invasion/microenvironment > ECM > Extracellular matrix Immunology > Innate Immunity > Complement > Regulatory Immunology > Innate Immunity > Macrophage / Inflamm. Immunology > Innate Immunity > NK Cells Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Adhesion molecules ELISA kits Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Angiogenic factors ELISA kits Microbiology > Protein > Human Protein > Defensin Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > Other Enzymes Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > Elastin Signal Transduction > Signaling Pathway > Calcium Signaling |
| 亚基 | Interacts with NOTCH2NL. |
| 组织特异性 | Bone marrow cells. |
| 相似性 | Belongs to the peptidase S1 family. Elastase subfamily. Contains 1 peptidase S1 domain. |
| 功能 | Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]. |
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