Recombinant human HLA-C & Beta
-2-MG Heterodimer protein, C-His (HEK293)(bs-43093P)-100ug/500ug/20ug- ￥680 - 6880
- Bioss
- bs-43093P
- 2025年10月16日
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100ug/500ug/20ug
| 规格： | 100ug | 产品价格： | ￥2280.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥6880.0 |
| 规格： | 20ug | 产品价格： | ￥680.0 |
| 产品编号 | bs-43093P |
| 英文名称 | Recombinant human HLA-C & Beta-2-MG Heterodimer protein, C-His (HEK293) |
| 中文名称 | 重组人组织相容性复合体蛋白 |
| 英文别名 | HLA-C; Major Histocompatibility Complex, Class I; HLA Class I Histocompatibility Antigen, C Alpha Chain; HLA-JY3; D6S204; PSORS1; HLAC; Major Histocompatibility Antigen HLA-C; MHC Class I Antigen Heavy Chain HLA-C; Human Leukocyte Antigen-C Alpha Chain; Psoriasis Susceptibility 1; Human Leukocyte Antigen C; HLA-C Antigen; HLA-Cw; HLC-C; MHC; HLAC_HUMAN; Recombinant human HLA-C / Beta-2-MG Heterodimer protein, C-His (HEK293) |
| 性状 | Lyophilized or Liqui |
| 纯化方法 | AC |
| 浓度 | ＞0.5 mg/ml |
| 研究领域 | Immunology > Adaptive Immunity > MHC > Class I Microbiology > Interspecies Interaction > Host Virus Interaction |
| 亚基 | Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein. Interacts with HTLV-1 p12I accessory protein. |
| 亚细胞定位 | Cell Membrane; Type I membrane protein. |
| 翻译后修饰 | N-linked glycosylation at Asn-110 is required for efficient interaction with CANX and CALR chaperones and appropriate HLA-C-B2M folded conformers prior to peptide loading |
| 相似性 | Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain. |
| 功能 | HLA-C (Major Histocompatibility Complex, Class I, C) is a Protein Coding gene. Diseases associated with HLA-C include Psoriasis 1 and Human immunodeficiency virus Type 1. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and TAP binding. An important paralog of this gene is HLA-B. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. About 6000 HLA-C alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the Human immunodeficiency virus (HIV), and the Severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020] |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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Recombinant human HLA-C & Beta-2-MG Heterodimer protein, C-His (HEK293)(bs-43093P)-100ug/500ug/20ug
￥680 - 6880
