- ￥880
- Bioss
- bs-0717P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-0717P |
| 英文名称 | Mastrin Antibody Blocking Peptide |
| 中文名称 | 精子相关抗原5封闭多肽 |
| 英文别名 | Astrin; Deepest; hMAP 126; hMAP126; MAP 126; Mitotic spindle associated protein; Mitotic spindle associated protein p126; Mitotic spindle coiled coil related protein; SPAG 5; SPAG5; Sperm associated antigen 5; Sperm tail protein Spag 5; Sperm tail protein Spag5; SPAG5_HUMAN. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 亚基 | Homodimer, with a globular head domain and a long stalk. Homooligomer; the globular head domains associate, resulting in aster-like structures. Binds to microtubules in the mitotic spindle. Interacts with DCLRE1B/Apollo. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGOL2. Interacts with KNSTRN. |
| 亚细胞定位 | Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore. Note=In a punctate pattern in interphase cells. During mitosis, detected at spindle poles during prophase, throughout the spindle in metaphase and anaphase, and at midzone microtubules in anaphase and telophase. Detected on kinetochores of chromosomes that have congressed. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends. |
| 组织特异性 | Highly expressed in testis. Detected at low levels in placenta, liver, pancreas, thymus and colon. |
| 功能 | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | A novel gene product, hMAP126, interacts with p29 in the yeast two-hybrid assay. The subcellular distribution of hMAP126 was localized to the mitotic spindle and is phosphorylated by p34(cdc2) kinase. Human MAP126 is likely involved in the functional and dynamic regulation of mitotic spindles. |
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Mastrin Antibody Blocking Peptide(bs-0717P)-500ug
￥880
