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- Bioss
- bs-11064P
- 2025年10月16日
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500ug
| 产品编号 | bs-11064P |
| 英文名称 | SPON2 Antibody Blocking Peptide |
| 中文名称 | 细胞外基质底物反应蛋白2封闭多肽 |
| 英文别名 | M spondin; Mindin; SPON 2; Differentially expressed in cancerous and non-cancerous lung cells 1; DIL 1; DIL-1; DIL1; M spondin; Mindin; Spon2; SPON2_HUMAN; Spondin 2; Spondin-2. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Innate Immunity > Macrophage / Inflamm. Neuroscience > Cell Adhesion Proteins > ECM Proteins Neuroscience > Cell Adhesion Proteins > Membrane Proteins Neuroscience > Neurology process > Neurogenesis Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > Other ECM Proteins |
| 亚基 | Monomer. Interacts with integrin. |
| 亚细胞定位 | Secreted; extracellular space; extracellular matrix. |
| 组织特异性 | Expressed in normal lung tissue but not in lung carcinoma cell lines. |
| 相似性 | Contains 1 spondin domain. Contains 1 TSP type-1 domain. |
| 功能 | Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The Thrombospondin proteins, Thrombospondins 1-4 and Thrombospondin 5 (also designated COMP), compose a family of glycoproteins that are involved in cell-to-cell and cell-to-matrix signaling. These extracellular, cell-surface proteins form complexes of both homo- and heteromultimers. Spondin-2, or Mindin, is also designated DIL-1 for its differential expression in cancerous and non-cancerous lung cells. Full-length SPON2 cDNA encodes a 331 amino acid protein with a domain arrangement similar to zebrafish F-Spondin and Mindin-1/Mindin-2: an FS1 domain, an FS2 domain, a hydrophobic signal sequence in the N-terminus and a Thrombospondin type I repeat. Immunoblot analysis demonstrates expression of dimers and oligomers in a concentration-dependent manner under nonreducing conditions. |
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SPON2 Antibody Blocking Peptide(bs-11064P)-500ug
￥880
