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500ug
| 产品编号 | bs-12394P |
| 英文名称 | DTX2 Antibody Blocking Peptide |
| 中文名称 | 锌离子结合蛋白DTX2封闭多肽 |
| 英文别名 | Deltex 2; Deltex2; hDTX2; Highly similar to hPMSR6 [H.sapiens]; Protein deltex 2; RING finger protein 58; RNF58; Zinc ion binding protein; DTX2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Stem Cells > Signaling Pathways > Notch > Cytoplasmic Stem Cells > Signaling Pathways > Notch > Nuclear |
| 亚基 | Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1. |
| 亚细胞定位 | Cytoplasmic and Nuclear. |
| 相似性 | Belongs to the Deltex family. Contains 1 RING-type zinc finger. Contains 2 WWE domains. |
| 功能 | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | DTX2 belongs to the Deltex family. It contains one RING-type zinc finger and two WWE domains. DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context; mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. DTX2 also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. There are two named isoforms. |
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DTX2 Antibody Blocking Peptide(bs-12394P)-500ug
￥880
