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- Bioss
- bs-13657P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-13657P |
| 英文名称 | NSP3 Antibody Blocking Peptide |
| 中文名称 | SH2结构域蛋白3A封闭多肽 |
| 英文别名 | Cas/HEF1 associated signal transducer; CHAT; FLJ39664; Novel SH2 containing protein 3; Novel SH2-containing protein 3; NSP 3; PRO34088; SH2 domain containing 3C; SH2 domain containing Eph receptor binding protein 1; SH2 domain containing protein 3C; SH2 domain-containing protein 3C; SH2D3_HUMAN; SH2D3C; Shep1. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Adapters > Cytoplasmic |
| 亚细胞定位 | Cytoplasm. Membrane. Associated with the membrane when EGF-stimulated. Found at ruffling membranes. |
| 组织特异性 | Ubiquitously expressed. |
| 相似性 | Contains 1 Ras-GEF domain. Contains 1 SH2 domain. |
| 功能 | Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors (1,2). These receptors, designated TNF-R1 and TNF-R2, are expressed on most cell types (1,3). The majority of TNF functions are primarily mediated through TNF-R1 (1,4). FAN (for factor associated with neutral sphingomyelinase (N-SMase) activation) is an intermediate protein that interacts with TNF-R1 to initiate TNF signaling events. FAN binds to TNF-R1 at the cytoplasmic NSD (N-SMase activating domain), which results in the initiation of the N-SMase pathway (5). N-SMase has been shown to be involved in TNF-induced Raf-1 activation (6). FAN contains four carboxy-terminal WD-repeat domains which appear to be involved in protein-protein interaction. The FAN WD-repeats may mediate the interaction between FAN and TNF-R1 (5). |
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NSP3 Antibody Blocking Peptide(bs-13657P)-500ug
￥880
