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- bs-12393P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-12393P |
| 英文名称 | BCL9 Antibody Blocking Peptide |
| 中文名称 | B淋巴细胞淋巴瘤因子9封闭多肽 |
| 英文别名 | B-cell CLL/lymphoma 9; BCL 9; BCL-9; DLNB11; Legless homolog; B-cell CLL/lymphoma 9-like; LGS; BCL9_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Proto-oncogenes Stem Cells > Signaling Pathways > Notch > Nuclear |
| 亚基 | Binds to beta-catenin (CTNNB1), PYGO1 and PYGO2. |
| 亚细胞定位 | Nuclear |
| 组织特异性 | Detected at low levels in thymus, prostate, testis, ovary and small intestine, and at lower levels in spleen, colon and blood. |
| 翻译后修饰 | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the BCL9 family. |
| 功能 | BCL9 is involved in signal transduction through the Wnt pathway. It promotes beta-catenin's transcriptional activity. BCL9 is associated with B-cell acute lymphoblastic leukemia. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies (referenced from swissprot and entrez gene). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Bcl-9L is a 1,499 amino acid protein that localizes to the nucleus and contains a specialized C-terminal domain that is important for its overall activity. Expressed in breast tissue, as well as in eye, lung, prostate and various carcinomas, Bcl-9L functions as a transcriptional activator that forms a complex with Parafibromin and β-catenin and is thought promote the transcriptional activity of Parafibromin and enhance the neoplastic transforming activity of β-catenin. Bcl-9L exists as multiple alternatively spliced isoforms and is thought to be involved in tumorigenesis, possibly playing a role in tumor transformation and metastasis. The gene encoding Bcl-9L maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11. |
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BCL9 Antibody Blocking Peptide(bs-12393P)-500ug
￥880
