HDGFRP3 Antibody Blocking Peptide(bs-16464P)-500ug

HDGFRP3 Antibody Blocking Pept

ide(bs-16464P)-500ug
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  • ¥880
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  • bs-16464P
  • 2025年10月16日
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      500ug

    产品编号bs-16464P
    英文名称HDGFRP3 Antibody Blocking Peptide
    中文名称肝癌衍生生长因子相关蛋白3封闭多肽
    英文别名CGI 142; HDGF 2; HDGF-2; HDGF2; HDGFRP 3; Hdgfrp3; HDGR3_HUMAN; Hepatoma derived growth factor 2; Hepatoma derived growth factor related protein 3; Hepatoma-derived growth factor 2; Hepatoma-derived growth factor-related protein 3; HRP 3; HRP-3; HRP3.
    纯化方法HPLC
    亚细胞定位Nucleus.
    组织特异性Detected in testis, heart, spinal cord and brain.
    相似性Belongs to the HDGF family.
    Contains 1 PWWP domain.
    功能Enhances DNA synthesis and may play a role in cell proliferation.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Hepatoma derived growth factor (HDGF) is the original member of a family of polypeptides designated HDGF-related proteins (HRPs). HDGF was initially characterized as a secreted mitogen from the Huh-7 human hepatoma cell line. This nuclear targeted vascular smooth muscle cell mitogen (VSM) is a heparin-binding protein that is highly expressed in tumor cells, where it stimulates proliferation. HDGF is also reported to be involved in organ development and lung remodeling after injury by promoting proliferation of lung epithelial cells. During development, HDGF expression is high in the nucleus and cytoplasm of smooth muscle and endothelial cells. The HRP family contains four proteins, HRP-1, HRP-2, HRP-3 and HRP-4. HRP-1 and HRP-4 are expressed only in testis, while HRP-2 is widely expressed in different tissues. HRP-3 can be found solely in the nervous system. Specifically it is strongly expressed in bulbus, olfactorius, piriform cotrex and amygdala complex, while HRP-2 in brain is located in the the thalamus, prefrontal and parietal cortex, neurohypophysis and cerebellum. In the central nervous system, HRPs play a role in neuron proliferation and cell survival.

     

     

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