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- bs-11058P
- 2025年10月16日
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500ug
| 产品编号 | bs-11058P |
| 英文名称 | APBA3 Antibody Blocking Peptide |
| 中文名称 | β淀粉样前体蛋白结合蛋白3封闭多肽 |
| 英文别名 | Adapter protein X11gamma; amyloid beta (A4) precursor protein binding, family A, member 3; Amyloid beta precursor protein binding, family A, member 3 phosphotyrosine binding/ interacting domain (PTB) bearing protein; APBA3; lin 10; MGC:15815; Mint 3; Mint3; Mint-3; Neuron specific X11L2 protein; Neuronal Munc18 1 interacting protein 3; phosphotyrosine binding/interacting domain (PTB) bearing protein; X11 like 2 protein 2; X11gamma; X11L2; APBA3_RAT. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Adhesion Proteins > ECM Proteins Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease > Amyloid Neuroscience > Neurotransmission > Secretory Vesicles |
| 亚基 | Binds to the cytoplasmic domain of amyloid protein (APP). Interacts with HIF1AN (via N-terminus) (By similarity). |
| 亚细胞定位 | Cytoplasm; perinuclear region. |
| 组织特异性 | Ubiquitous. |
| 相似性 | Contains 2 PDZ (DHR) domains. Contains 1 PID domain. |
| 功能 | May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the Beta-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 (Mint 3). |
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APBA3 Antibody Blocking Peptide(bs-11058P)-500ug
￥880
