- ￥880
- Bioss
- bs-11038P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-11038P |
| 英文名称 | MYRIP/SLAC2-C Antibody Blocking Peptide |
| 中文名称 | MYRIP蛋白封闭多肽 |
| 英文别名 | exophilin 8; exophilin; Exophilin-8; Exophilin8; Myosin VIIA and Rab interacting protein; Myosin-VIIa- and Rab-interacting protein; MyRIP; MYRIP_HUMAN; rab effector MYRIP; SLAC 2C; SLAC2 C; SLAC2-C; SLAC2C; Slp homolog lacking C2 domains c; Slp homologue lacking C2 domains; Slp homologue lacking C2 domains c antibody Synaptotagmin like protein homologue lacking C2 domains c; synaptotagmin-like protein homologue lacking C2 domains-c. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Adhesion Proteins > Cytoskeletal Proteins > Thin Filaments Neuroscience > Cell Type Marker > Neuron marker > Synapse marker Neuroscience > Neurotransmission > Secretory Vesicles Neuroscience > Neurotransmission > Secretory Vesicles > Munc18 |
| 亚基 | Binds MYO5A, MYO7A and F-actin. Binds RAB27A that has been activated by GTP-binding via its N-terminus. Interacts with PRKAR2A. Interacts with components of the exocyst complex, including EXOC3 and EXOC4. |
| 亚细胞定位 | Cytoplasm. In pre- and post-synaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments. |
| 组织特异性 | Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis. |
| 相似性 | Contains 1 FYVE-type zinc finger.
Contains 1 RabBD (Rab-binding) domain. |
| 功能 | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Slac2-c is a Rab effector protein that is expressed in a variety of tissues including brain, heart, skin and liver. Found in the basal microvilli of retinal pigment cells and in pre- and post-synaptic areas in photoreceptor cells , Slac2-c is involved in melanosome transport and functions to link Rab 27a with the actin-based motor proteins Myosin Va and Myosin VIIa. Once linked, the Myosins are able to transport Rab 27a to retinal melanosomes, thereby linking the actin cytoskeleton with the melanosome membrane. Slac2-c contains one FYVE-type zinc finger and one Rab-binding domain and is able to bind actin-like proteins through its conserved C-terminal region. Additionally, Slac2-c is thought to regulate the final steps of insulin exocytosis by mediating the interaction of secretory granules with the cortical actin cytoskeleton. |
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MYRIP/SLAC2-C Antibody Blocking Peptide(bs-11038P)-500ug
￥880
