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- Bioss
- bs-12369P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-12369P |
| 英文名称 | DUX4 Antibody Blocking Peptide |
| 中文名称 | 双同源框蛋白4封闭多肽 |
| 英文别名 | Double homeobox protein 10; Double homeobox protein 4; Double homeobox protein 4/10; DUX10; DUX4_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Stem Cells > Mesenchymal Stem Cells > Myogenesis |
| 亚基 | May exist as a monomer or a dimer. |
| 亚细胞定位 | Nucleus. Note=Actively transported through the nuclear pore complex (NPC). |
| 组织特异性 | Does not seem to be expressed in normal muscle, but in muscle of individuals with FSHD, where it may be toxic to cells. |
| 相似性 | Belongs to the paired homeobox family. Contains 2 homeobox DNA-binding domains. |
| 功能 | May be involved in transcriptional regulation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | DUX4 is a homeodomain protein with a similar protein sequence to Pax3 and Pax7. Defects in DUX4 may be the cause of facioscapulohumeral muscular dystrophy (FSHD). FSHD is characterized by weakness of the muscles of the face, upper-arm and shoulder girdle. Severity is highly variable. Weakness is slowly progressive and about 20% of affected individuals eventually require a wheelchair. Approximately 70-90% of individuals have inherited the disease-causing deletion from a parent, and approximately 10-30% of affected individuals have FSHD as the result of a de novo deletion. Offsprings of an affected individual have a 50% chance of inheriting the deletion. |
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DUX4 Antibody Blocking Peptide(bs-12369P)-500ug
￥880
