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500ug
| 产品编号 | bs-23351P |
| 英文名称 | SCLT1 Antibody Blocking Peptide |
| 中文名称 | 钠离子通道相关蛋白1封闭多肽 |
| 英文别名 | CAP-1A; CAP1A; FLJ30655; hCAP-1A; SAP1; SCLT1; SCLT1_HUMAN; Sodium channel and clathrin linker 1; Sodium channel-associated protein 1. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with SCN10A and clathrin. Identified in a complex containing SCN10A, clathrin and SCLT1 (By similarity). |
| 亚细胞定位 | Cytoplasm. Cell periphery. |
| 功能 | Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SCLT1 (sodium channel and clathrin linker 1), also known as CAP1A or hCAP-1A, is a 688 amino acid cytoplasmic protein that acts as a linker between the voltage-gated sodium channel, Na+ CP type X? and clathrin. SCLT1 is abundantly expressed in DRG (dorsal root ganglia) neurons and colocalizes with Na+ CP type X? SCLT1 regulates Na+ CP type X?channel activity by promoting channel internalization. SCLT1 exists as four alternatively spliced isoforms and is encoded by a gene located on human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. |
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SCLT1 Antibody Blocking Peptide(bs-23351P)-500ug
¥880







