- ￥880
- Bioss
- bs-17488P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-17488P |
| 英文名称 | CD209b Antibody Blocking Peptide |
| 中文名称 | CD209b封闭多肽 |
| 英文别名 | SIGN Related 1; CD209 antigen like protein B; CD209b antigen; DC SIGN related protein 1; DC SIGNR1; OtB7. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Membrane Single-pass type II membrane protein |
| 组织特异性 | Expressed in skin, spleen and lung, probably in a subset of dendritic cells. Detected in spleen extrafollicular paracortical areas including the red pulp and marginal zones, and at lower levels, in the follicular area. Detected in skin suprabasal areas adjacent to the epidermis and in epidermal cell layer. |
| 相似性 | Contains 1 C-type lectin domain. |
| 功能 | SIGN R1 is a specific marker for the identification of macrophage subpopulations present in the marginal zone of spleen (the so-called marginal zone macrophages (MZM)), in the lymph node medulla, and in some strains, in the peritoneal cavity. MZM of the spleen are involved in the clearance of polysaccharides. Mouse SIGN R1 is a C type lectin, like DC SIGN which is expressed on Human dendritic cells (DCs). However, Mmouse SIGN R1 itself is not expressed on DCs. SIGN R1 exists in an aggregated form, resistant to dissociation into monomers upon boiling in SDS under reducing conditions. SIGN R1 mediates the uptake of encapsulated organisms and may be an important mediator for the uptake of microbes in both spleen and lymph node, particularly through the recognition of microbial polysaccharides. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Antigen-presenting cells are localized in essentially every tissue, where they operate at the interface of innate and acquired immunity by capturing pathogens and presenting pathogen-derived peptides to T cells. Dendritic cells capture antigens or viruses in peripheral tissue and transport them to lymphoid organs, an event that induces cellular T cell responses. The mouse CD209 family of cell adhesion receptors consists of CD209a (also known as DC-SIGN), CD209b, CD209c, CD209d, CD209e, CD209f and CD209g, all of which function to mediate the endocytosis and subsequent degradation of pathogens within lysosomal compartments. There are two human CD209 proteins, designated DC-SIGN and DC-SIGNR, which function in a similar manner to the mouse proteins. |
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CD209b Antibody Blocking Peptide(bs-17488P)-500ug
￥880
